New Delhi: A study by researchers from the Indian Council of Medical Research (ICMR) found neutralizing antibodies against the delta variant (B1.617.2) in serum samples of 58.1% of people who received a single dose of Kovidhield vaccine. Did not see At the same time, neutralizing antibodies were not found in 16.1% of the samples of people who took two doses.
According to Dr. T. Jacob John, former Head of the Department of Microbiology, Christian Medical College, Vellore" Antibodies not being visible and not being present are not the same thing. It may be that the level of neutralizing antibody is very low, which is not detected. But it can be present and protect the person from infection, serious illness.”
inhibits the entry of the CoV-2 virus into cells. Titres of neutralizing antibodies, which specifically target the Sars-CoV-2 virus and kill it or humans prevent them from entering the cells. These titres were lower against the delta variant than against the B1 variant. The first wave of infection came in India due to the B1 variant. Compared to B1, neutralizing antibody titres against the delta variant were 78% lower in people taking one dose of the vaccine, 69% lower in those taking two doses. Apart from this, people who have been infected and have taken a dose were 66% less. In addition, those who had the infection and took both shots were 38% less likely.
The study means that some in India’s vaccination campaign may need an additional booster shot in addition to Kovidshield, while those who have the infection may only need one dose. is.
One dose may be enough for people who have been infected
Dr. According to John, "Assuming that the serum used for the study was from healthy individuals, the level of neutralizing antibodies would be higher in those who are elderly, have pre-existing diseases, because their immune responses are low. This means that men over 65 years of age (women produce higher levels of antibodies), people with diabetes, high blood pressure, heart, lung, kidney diseases, or those undergoing cancer treatment should be given a third dose . On the other hand, a single dose is enough to trigger an immune response in people who have been infected."
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